Abstract: In this paper, γ-Al₂O₃ supported nickel, manganese, cobalt, and other metal oxide catalysts were prepared by the impregnation method respectively, and its ozone catalytic decomposition performance was studied at 25 ℃ under a WHSV of 200000 mL/(g_cat·h). The results showed that 10% NiO/γ-Al₂O₃ catalyst demonstrates superior catalytic activity, and the ozone conversion rate is higher than 96% within 20 h. According to the characterizations of XRD, XPS, TEM, SEM-EDS and H₂-TPR, its excellent ozone may be attributed to the formation of NiAl₂O₄ spinel on the surface of NiO/γ-Al₂O₃ catalyst. Furthermore, the mechanism of ozone decomposition on different transition metal oxide catalysts is divergent. The related study sheds new light on the reaction mechanism of ozone catalytic decomposition over transition metal oxides such as nickel and manganese, it also provides the guidelines for the development of efficient ozone decomposition catalysts.