Abstract: Catalytic combustion is an effective approach to remove volatile organic compounds, in which the development of highly active and durable catalyst is extremely crucial. Herein, a series of CuMnCe_x/Al₂O₃/cordierite monolithic catalysts were synthesized by using the ultrasonic-assisted impregnation method. The physicochemical properties were comprehensively characterized via the BET, XRD, SEM, EDX, H₂-TPR, O₂-TPD, XPS and EPR techniques. The results showed that the catalytic activity of CuMnCe_x/Al₂O₃/Cor for toluene combustion was strongly affected by the Ce content. The CuMnCe₂/Al₂O₃/Cor monolithic catalyst showed the best catalytic activity with toluene conversion of 90% at 263 °C under toluene concentration of 1 g/L and space velocity of 78000 mL/(g·h). Meanwhile, the well-dispersed CeO₂ in the CuMn matrix not only improved the content of oxygen vacancies and the mobility of oxygen species, but also enhanced the low-temperature reducibility of the catalyst. Moreover, the CuMnCe₂/Al₂O₃/Cor monolithic catalyst exhibited an excellent stability in the long-term test and cycle ability test.