Abstract: CuO/CeZrO₂ catalysts doped with different amounts of Dy₂O₃ and Y₂O₃ were prepared by the hydrothermal-impregnation method and characterized by XRD, H₂-TPR and nitrogen sorption; the effect of Dy and Y doping on the catalytic performance of CuO/CeZrO₂ for the preferential oxidation of CO in H₂-rich stream was investigated. The results indicate that all the CuO/CeZrO₂ catalysts have a fluorite structure; doping with appropriate amounts of Dy₂O₃ and Y₂O₃ can improve the interaction between the active component and support, the dispersion of CuO and its reducibility at low temperature, which is effective to enhance the activity of Dy and Y doped CuO/CeZrO₂ catalysts in the preferential oxidation of CO. Moreover, the doping with Dy₂O₃ and Y₂O₃ can also reduce the inhibition effect of CO₂ on CuO/CeZrO₂ in CO oxidation and then improve its catalytic stability.