Abstract: A series of V-Cr/SBA-15 catalysts with different V and Cr contents were prepared by the incipient wetness impregnation method. The structure of the catalysts was characterized by XRD, BET and TPR technique. The catalytic activity of the catalysts for the propane oxidative dehydrogenation with CO2 to propene was evaluated using a fixed bed reactor. The results show that vanadium and chromium oxide were well dispersed on the surface of SBA-15 and the structure of the SBA-15 was not destroyed during the impregnation. The catalytic activity of the catalysts depended on the loading of vanadium and chromium. The V and Cr bimetallic catalysts had better performance than those of the single metallic catalysts. The TPR results showed that there was the strong interaction between the vanadium oxide and the chromium oxide in the V-Cr/SBA-15 catalysts. This interaction remarkably changed the redox properties of the catalysts.