Abstract: Oxidative deep desulfurization was considered as one of the most promising nonHDS process. In the present work, thiophene selective oxidation was studied over TS-1 using hydrogen peroxide as oxidant in model gasoline. The oxidation of thiophene was investigated in the presence of hydrocarbons. Effect of these typical hydrocarbons on selective oxidation of thiophene can be obtained: n-octane and cyclohexane have no effect on removal of thiophene from model gasoline. Benzene also has no effect on final thiophene removal from model gasoline, but has a little effect on initial removal rate of thiophene. n-Octene will seriously influence the removal of thiophene from model gasoline. Therefore further study is required to improve the selectivity of TS-1 in model gasoline containing alkene. Loading silver or copper on TS-1 will increase its selectivity in thiophene oxidative removal from model gasoline containing alkene. The best amount of silver or copper on TS-1 is 0.05% or 0.07%,respectively.