Abstract: Circulating entrained bed reactor has many good characteristics as follows: good mass transfer, good solid suspending, little axial backmixing, sufficient contact of different phase, wide adjustable range of gasliquid ratio and high efficiency of catalyst. Study on methanol synthesis has been carried out in the hot model experimental apparatus, and the effects of these factors such as slurry recirculation flow rate，space velocity，concentration of catalyst, the number of nozzle on the methanol synthesis has been investigated in the present study. The results show that the outlet product concentration and spacetime yield increase with slurry recirculation flow rate, concentration of catalyst and the number of nozzle. High space velocity of syngas enhanced the spacetime yield of catalyst，but decreased the outlet product concentration.