Abstract: Ni-based catalysts with different supports were prepared for methane dry reforming. The obtained catalysts were characterized by N₂ physisorption, XRD, H₂-TPR, H₂-chemisorption, and so on. It was revealed that the support had significant influence on the state of NiO species. SiO₂, TiO₂ and ZrO₂ had weak interaction with NiO, facilitating the reduction of the corresponding catalysts. Al₂O₃ and MgO have strong interaction with NiO, making them very difficult to be reduced. Al₂O₃ modified by MgO has both proper texture properties and interaction strength between metal and support, which were in favor of the dispersion and stabilization of NiO species. Superior catalytic performance was observed over this catalyst under very high gas hourly space velocity. Stable catalytic performance was achieved during a long term run of more than 100h.