Abstract: CuO-CeO₂ monolithic catalysts supported on SiO₂-Al₂O₃ modified glass-fiber honeycomb were prepared via co-impregnation method and their performance in the oxidation of volatile organic compounds (VOCs) such as ethyl acetate, isopropanol and toluene was evaluated. Various techniques such as N₂ sorption, X-ray powder diffraction (XRD), hydrogen-temperature programmed reduction (H₂-TPR), ammonia-temperature programmed desorption (NH₃-TPD) and chemisorption of VOCs were employed to characterize the catalysts. The results show that the copper oxide species are highly dispersed on the CuO-CeO₂ based catalysts; moreover, the size of CeO₂ nanoparticles increases with the decrease of copper/ceria molar ratio. The addition of ceria oxide can evidently increase the amount of total acid sites, especially the Lewis ones, which can enhance the adsorption capacity of ethyl acetate and isopropanaol and promote the oxidation of ethyl acetate and isopropanaol. In the case of toluene combustion, the addition of large amount of CeO₂ may decrease the reducibility and oxygen activation capability; as a result, it contributes little to the adsorption of toluene, resulting in a low activity in the oxidation of toluene. The catalytic activity is related both to the reactivity of surface oxygen and to the adsorption capacity of the catalyst towards VOC molecules, which are determined by the complex interactions among copper, cerium oxide and the support.