Abstract: In this paper, we studied the effects of supports, such as SiO₂, MgO, Al₂O₃ and MgAl₂O₄, on the performance of supported NiSn catalyst for propane dehydrogenation. NH₃ temperature-programmed desorption, H₂ temperature-programmed reduction were applied for the characterization of the catalysts. The results show that SiO₂ with large specific surface area and large pore size can achieve good contact between catalyst and reactants, leading to a high content of Ni_2.67Sn₂ alloy and a reduced diffusion resistance, In addition, their weak acid improve dehydrogenation activity and propene selectivity.